Impaired Mitochondria And Intracellular Calcium Transients In The Salivary Glands Of Obese Rats Pdf

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impaired mitochondria and intracellular calcium transients in the salivary glands of obese rats pdf

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The ER controls the synthesis, modification, folding, and export of proteins. An imbalance between the demand for protein synthesis and the capacity to handle them leads to the accumulation of misfolded or unfolded proteins, which is referred to as ER stress.

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Al Kury, M. Smail, M. Qureshi, V. Sydorenko, A.

Impaired mitochondria and intracellular calcium transients in the salivary glands of obese rats

The process of saliva production in the salivary glands requires transepithelial water transfer from the interstitium to the acinar lumen. There are two transepithelial pathways: the transcellular and paracellular. In the transcellular pathway, the aquaporin water channels induce passive water diffusion across the membrane lipid bilayer. It is well known that aquaporin-5 AQP5 is expressed in the salivary glands, in which it is mainly localized at the apical membrane of the acinar cells. This suggests the physiological importance of AQP5 in transcellular water transfer. Reduced saliva secretion under pilocarpine stimulation in AQP5-null mice compared with normal mice further indicates the importance of AQP5 in this process, at least in stimulated saliva secretion.

Salivary Glands. Tumors rarely involve more than Malignant tumors of the major salivary glands can Dry mouth or dry eyes are common. This may occur with other systemic Salivary gland disease. Salivary gland disease covers a wide range of pathological entities, including salivary gland -specific disease, as well as manifestations of systemic diseases.

Linking calcium signaling and mitochondrial function in fungal drug resistance.

In this review, we will summarise the recent advances in the field, with a special focus on the translational aspects of the basic findings. Acute pancreatitis AP is an inflammatory disease of the pancreas associated with significant morbidity and mortality. AP is one of the most frequent causes of hospitalisation among non-malignant gastrointestinal disorders, whereas the global disease incidence has increased in the past several decades [ 1 , 2 , 3 ]. AP is primarily caused by impacted gallstones or heavy alcohol consumption; however, the incidence of iatrogenic AP caused by endoscopic retrograde cholangiopancreatography ERCP or drug administration such as L-asparaginase has also increased [ 5 ]. It also improves the severity of cerulein, bile acid or fatty acid ethyl ester FAEE -induced experimental AP in mice [ 13 ]. Genetic or pharmacologic inhibition of the MPTP resulted in the improvement of the AP phenotype and acinar [ 16 ] and ductal [ 17 ] cell injury both in vitro and in vivo. On the other hand, Gpbar1 knockout mice were protected against taurolithocholic acid 3-sulfate-induced AP, an experimental model of biliary AP.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. Author contributions: P. The host range for Aspergillus fumigatus is wide, including mammals, aves, and insecta stonebrood. This is linked to the significant adaptability of this important fungal pathogen.


However, the effect of obese-insulin resistance on salivary glands has not been Rats were then sacrificed and submandibular glands were removed to mitochondrial function and dynamics, and intracellular calcium transient signaling.


Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

Electronic address:. Toggle navigation. Login Categories Journals. Publications by authors named "J Ittichaicharoen".

Zymogen granules ZG are located at the apex of pancreatic acinar cells. The regulated discharge of stored macromolecules is accompanied by secretion of solutes and water to the cell exterior to fluidize these protein-rich secretory products. This review provides a current update of studies that have been mainly published in the postgenomic era and identified cloned transporters and ion channels in the membrane of ZG.

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Endoplasmic-Reticulum Calcium Depletion and Disease

Publications by authors named "J Ittichaicharoen"

Metrics details. They also serve as master switches determining cell fate on exposure to different stimuli [ 1 — 3 ]. The characteristics and physiological and pathophysiological functions of this protein, and its associated proteins have been widely studied [ 6 — 8 ].

Джабба глубоко вздохнул и понизил голос. - Вирусы, - сказал он, вытирая рукой пот со лба, - имеют привычку размножаться. Клонировать самих .

Impaired mitochondria and intracellular calcium transients in the salivary glands of obese rats

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Беккер молчал. - Ja. Дверь слегка приоткрылась, и на него уставилось круглое немецкое лицо. Дэвид приветливо улыбнулся. Он не знал, как зовут этого человека. - Deutscher, ja. Вы немец.

Разве не так, коммандер. - Ни в коем случае! - отрезал Стратмор. Хейл вскипел: - Послушайте меня, старина. Вы отпускаете меня и Сьюзан на вашем лифте, мы уезжаем, и через несколько часов я ее отпускаю. Стратмор понял, что ставки повышаются. Он впутал в это дело Сьюзан и должен ее вызволить.

Червь ползет с удвоенной скоростью. У нас осталось всего восемь минут. Мы ищем число, а не произвольный набор букв.

 Ну… - произнес голос.  - Он очень, очень полный.

 Что. - Местная валюта, - безучастно сказал пилот. - Я понимаю.  - Беккер запнулся.  - Но тут… тут слишком .

 Подождите, - сказала Сьюзан, заглядывая через плечо Соши.  - Есть еще кое-что.

3 Comments

  1. Ysmael T. 01.06.2021 at 05:35

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    Impaired mitochondria and intracellular calcium transients in the salivary glands of obese rats. Jitjiroj Ittichaicharoen, Nattayaporn Apaijai.

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